Atherosclerosis – Cardiovascular Disease.?

Atherosclerosis is a disease affecting arterial blood vessels. It is a chronic inflammatory response in the walls of arteries, in large part due to the accumulation of macrophage white blood cells and promoted by low density (especially small particle) lipoproteins (plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high density lipoproteins (HDL), (see apoA-1 Milano). It is commonly referred to as a "hardening" or "furring" of the arteries. It is caused by the formation of multiple plaques within the arteries.

What are three events which lead to this sort of artery damage?

is it this?
The atheromatous plaque is divided into three distinct components:

1. The atheroma ("lump of porridge", from Athera, porridge in Greek,), which is the nodular accumulation of a soft, flaky, yellowish material at the center of large plaques, composed of macrophages nearest the lumen of the artery
2. Underlying areas of cholesterol crystals
3. Calcification at the outer base of older/more advanced lesions.

Because im not sure….

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One Response to “Atherosclerosis – Cardiovascular Disease.?”

  1. EyesOnly Says:

    Hello Moir.

    I am afraid the cascade of events that you have mentioned is not what causes the atherosclerosis.

    Here is what is believed to happen.

    1- Hypercholesterolemia and/or hyperglycemia or any disease for that matter causes a sort of injury to the endothelial lining.
    2- This injury is followed by sunendothelial migration of monocytes and the accumulation of fatty streaks containing lipid rich macrophages and T-cells.
    3- Several mediators are then released and collagen is formed.
    4- Collagen then attracts the platelets and a fibrous cap as well as necrotic cells are formed. This leads to plaque formation.
    5- The resulting atherosclerotic plaque results in loss of endothelium function and loss of the blood vessel’s elasticity.
    6- Depending on the location of this affected blood vessel, angina, stroke, or sever spasm can occur.

    God bless.